Intestinal homeostasis in the prevention of pediatric obesity and its consequences on health


Early life obesity carries increased risks of inflammatory and metabolic diseases later in life. Given the increase in childhood obesity, and the increase in chronic diseases, it is an important Public Health objective to develop preventive methods to childhood obesity. One approach ishealthy nutrition of mother and child, another approach is complementation of nutrition, the best approach being dictated by societal conventions.

The objective of this project is to assess the efficacy of dietary fibers, short chain fatty acids and tryptophan metabolites, and of the bacteria speciesable to process fibers and tryptophan, in the prevention of childhood obesity and associated risks.

If successful, this project will pave the way to design of nutritional complements that can be administered to both mothers and sucklings in order to prevent early life obesity. The most important benefit of this project, if successful,is to prevent childhood obesity, which increases the risks of inflammatory pathologies later in life, such as allergy and autoimmunity, as well as of metabolic diseases such as diabetes.

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